I want to remove a NPC(or replace).How i do it?

[StriderEdu]

I want to remove a npc(or replace), for exemple: Jesse.There are a mod or code for it?How i do it?
 
Thanks.

[eshenk]

@StriderEdu Like the Nike bumper sticker says, "Just Do It!", LOL...

[StriderEdu]

i don't know how my friend, explain it to me please.