Re: modding with game on?[link text](![link url]([image ur l]([link url](link url))))
You can't install dlc, or make textures changes for example, while OpenIV is open. So you're very limited.
This a huge PITA if you install an addon, start the game, and realize you forgot to make any entry in dlclist.xml or peds.meta.
Scripts however can be reloaded quickly without having to restart game.
Similarly you can inspect changes in OpenIV while the game is running but once more you can't make changes.