This new update is driving me nuts.
Long story short, I have been modding this game since day one. When an update comes out its always the same procedure to get mods working, replace update.rpf, modify gameconfig and wait for Alex to update scripthook.
Well it appears these bastards at Rockstar have decided to throw a new wrench in the process with this update. I am 100% sure they have introduced some new memory limitation which is the source of all this CTD and disappearing texture issues being reported on here.
I boot into the game and gets passed the loading screen. My save is at Trevors strip joint. I test all peds and spawn a few vehicles, all work as expected. As soon an I walk or drive towards the bridge its an instant CTD. No error message, just crashes straight to desktop. So I thought OK, this is probably some ASI or script that is causing a collision because it needs to be updated. As I begin my process of elimination I start to realize it doesn't matter which RPF / ASI / Scripts I remove. the less mods I have, this invisible CTD barrier goes away. For example, if I disable any one my ped dlc.rpfs the CTD barrier now lets me traverse all of los santos up until the Airport.
My setup is exactly how it was before this piece of shit update. I have three modified rpfs in my mods folder (just ped and vehicles) along with a modified update.rpf which I have only modified the dlc and gameconfig xml.
I have tried multiple gameconfigs with no luck. The only thing that alleviates (does not fix) the problem is disabling random mods. The game is clearly now limiting what we can load into memory. At least that's what I have observed while troubleshooting this crap.