For some plugins, yes. Plugins like DLS and EUP that run completely independently of LSPDFR don't require it to be loaded in order to work. However, things that require you to put them into the LSPDFR plugin folder like callout packs, LSPDFR+, etc obviously require it to be loaded in order to work. You do need RPH in order for any plugin to work by the way.
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RE: LSPDFR Plugins loadable without LSPDFR?